A hemicryptophane with a triple-stranded helical structure

• Augustin Long,
• Olivier Perraud,
• Erwann Jeanneau,
• Christophe Aronica,
• Jean-Pierre Dutasta and
• Alexandre Martinez

Beilstein J. Org. Chem. 2018, 14, 1885–1889, doi:10.3762/bjoc.14.162

• retained in solution. Keywords: CTV; hemicryptophanes; organic cages; triple helical structure; Introduction Among the remarkable architectures found in biological systems, those presenting a triple helical arrangement are of particular interest. Beside its classical double strand structure formed by

• Watson–Crick base pairing, DNA can also organize in a triple helical fashion [1]. These three-stranded structures of DNA naturally occur and play important roles in regulating gene function and DNA metabolism. Collagen, the most abundant protein in animals, also adopts a triple helical structure: three

• a better understanding of the properties of this biological system and giving rise to numerous applications ranging from artificial collagenous biomaterials to peptides for therapeutic uses [3][4][5]. Recently, molecular cages presenting a triple helical structure have aroused a considerable

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties

• José L. Jiménez Blanco,
• Fernando Ortega-Caballero,
• Carmen Ortiz Mellet and
• José M. García Fernández

Beilstein J. Org. Chem. 2010, 6, No. 20, doi:10.3762/bjoc.6.20

• stoichiometry, similar to homo-polymeric thymidyl and adenyl DNA strands, which can form a triple helical structure. On the other hand, octameric cytidyl DNG 59 and mixed-based oligomers 61–63 form 1:1 complexes with complementary DNA oligomers. The trimeric 7-deazaguanidyl 60, in which guanine is replaced by 7